Parkinson disease

Parkinson disease in Gaucher disease

BACKGROUND Gaucher disease (GD) is an inborn error of metabolism caused by mutations in the gene (GBA) coding for glucocerebrosidase (GCase), inherited in an autosomal recessive pattern. GD patients have up to 9% risk of developing PD. CASE PRESENTATION We report two patients with GD that developed PD at different disease stages. CONCLUSION We reviewed the literature on the coexistence of P...

Vagotomy and Parkinson disease

OBJECTIVE To examine whether vagotomy decreases the risk of Parkinson disease (PD). METHODS Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978 selective) identified between 1970 and 2010 and 377,200 reference individuals from the general population individually matched to vagotomized patients by sex and year...

Genetics of Parkinson Disease

Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder second to Alzheimer’s disease, affecting 1-2% of individuals over 60 years of age, with a risk that increases with age. Its phenotypic complexity, characterized by motor (resting tremor, bradikinesia, rigidity and postural instability) and non-motor (autonomic dysfunction and cognitive impairment) symptoms...

Parkinson disease and exercise.

Parkinson disease (PD) is a progressive, neurodegenerative movement disorder. PD was originally attributed to neuronal loss within the substantia nigra pars compacta, and a concomitant loss of dopamine. PD is now thought to be a multisystem disorder that involves not only the dopaminergic system, but other neurotransmitter systems whose role may become more prominent as the disease progresses (...

Premotor Parkinson disease.